Alkylation Damage In Dna And Rna-Repair Mechanisms And Medical Significance

Alkylation damage in DNA and RNA--repair mechanisms and medical significance

https://www.ncbi.nlm.nih.gov/pubmed/15380096

Alkylation damage in DNA and RNA--repair mechanisms …

https://pubmed.ncbi.nlm.nih.gov/15380096/

Alkylation lesions in DNA and RNA result from endogenous compounds, environmental agents and alkylating drugs. Simple methylating agents, e.g. methylnitrosourea, tobacco-specific nitrosamines and drugs like temozolomide or …

Alkylation damage in DNA and RNA—repair …

https://www.sciencedirect.com/science/article/pii/S156878640400148X

In fact, all the main mechanisms of DNA repair (direct damage reversal, base excision repair, nucleotide excision repair (NER), mismatch repair and …

Alkylation damage in DNA and RNA—repair …

https://www.sciencedirect.com/science/article/abs/pii/S156878640400148X

It has only recently become evident that at least some types of RNA alkylations are also repaired. Whereas the significance of repair of alkylations in DNA is …

A DNA repair-independent role for alkyladenine DNA …

https://www.pnas.org/doi/10.1073/pnas.2111404119

Alkylation DNA damage can affect gene expression by direct structural hindrance of the transcriptional machinery or due to activation of the DNA repair …

The complexity and regulation of repair of alkylation …

https://www.tandfonline.com/doi/full/10.1080/10409238.2020.1869173

Over the last decades, their anti-proliferative effects have focused on the specific mechanisms by which they damage DNA, and the factors involved in the repair of such …

Alkylation damage in DNA and RNA—repair …

https://www.researchgate.net/publication/8335012_Alkylation_damage_in_DNA_and_RNA-repair_mechanisms_and_medical_significance

Alkylation lesions in DNA and RNA result from endogenous compounds, environmental agents and alkylating drugs. Simple methylating agents, e.g. …

Regulation of DNA Alkylation Damage Repair: Lessons …

https://pubmed.ncbi.nlm.nih.gov/27816326/

There is mounting evidence that the individual pathways function cooperatively, suggesting that coordinated regulation of alkylation repair is critical to prevent toxicity. …

Regulation of DNA Alkylation Damage Repair: Lessons …

https://www.sciencedirect.com/science/article/abs/pii/S0968000416301748

Even within a specific category of DNA damage, the machinery utilized for repair varies due to the chemistry of the damage, the damage context, differential …

Invited mini review Alkylation damage in DNA and …

https://folk.ntnu.no/drablos/papers/24_DNA_Repair_2004.pdf

while the relative contribution of alkylation damage is not well established. However, the mere existence of several spe-cific repair systems for alkylation damage indicates that …

Alkylation damage in DNA and RNA--repair mechanisms …

https://citeseer.ist.psu.edu/showciting?cid=4858393

Cells deleted for the polA (DNA polymerase I) or priA (primosome) genes are as sensitive to MMS and MNNG as alkA tag bacteria. Our results suggest that the mechanism of …