Knockout Animals In Biomedical Research

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Zebrafish as an animal model for biomedical research

https://www.nature.com/articles/s12276-021-00571-5

The knockout animals also exhibited contractures of the pectoral fins and abnormal eye positioning, suggestive of exotropia, indicating that zebrafish disease models can be used to study the...

Transgenic and Knock‐out Animals | SpringerLink

https://link.springer.com/referenceworkentry/10.1007/3-540-29623-9_1140

Animals into which additional and/or altered genetic information has been introduced are termed transgenic animals. Two principle technical approaches are used to generate …

Knockout Mice Fact Sheet - Genome.gov

https://www.genome.gov/about-genomics/fact-sheets/Knockout-Mice-Fact-Sheet

A knockout mouse is a laboratory mouse in which researchers have inactivated, or "knocked out," an existing gene by replacing it or disrupting it with an artificial piece of DNA. What are …

Transgenic animal models in biomedical research - PubMed

https://pubmed.ncbi.nlm.nih.gov/17172731/

Recently, animal models provided novel insight and significantly improved our understanding of the initiation and perpetuation of human diseases. Moreover, they are an invaluable …

Gene knockout animal models of depression, anxiety …

https://pubmed.ncbi.nlm.nih.gov/31464999/

Abstract. In the past decades, the improving knowledge of genes implicated in the pathogenesis of psychiatric disorders together with the advancements in genetic …

It's A Knockout: Mice Advancing Research As Lab …

https://www.the-scientist.com/news/its-a-knockout-mice-advancing-research-as-lab-animals-of-choice-58448

Animals carrying defective copies of genes are increasingly used in biomedical research laboratories as model systems for investigating the pathology of human disorders such as cancer, arthritis, …

Beyond knockout rats - PubMed Central (PMC)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100883/

Additionally, our strategy allows for the eGFP gene to be placed under Oct4 endogenous promoter control, serving as a reporter for targeting events in ES cells (Fig. …

The use of animals for research on animal diseases: its …

https://pubmed.ncbi.nlm.nih.gov/23577464/

Abstract. The use of animals in scientific experiments is sometimes controversial. Usually, the debate focuses on the advantages or disadvantages of using animals in biomedical …

A Knockout Experiment: Disciplinary Divides and …

https://pubmed.ncbi.nlm.nih.gov/26090739/

In the early 1990s, a set of new techniques for manipulating mouse DNA allowed researchers to 'knock out' specific genes and observe the effects of removing them on a …

Biomedical experimentation on animals — Animal Ethics

https://www.animal-ethics.org/animal-experimentation-introduction/biomedical-experimentation-animals/

Researchers keep these animals alive only because the death of animals during experiments may make the data less useful. Animals used for experimentation A wide …

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