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Vioxx, the implosion of Merck, and aftershocks at the FDA - The …
- https://www.thelancet.com/journals/lancet/article/PIIS0140673604175235/fulltext
- The licensing of Vioxx and its continued use in the face of unambiguous evidence of harm have been public-health catastrophes. This controversy will not end …
How Vioxx is changing US drug regulation - The Lancet
- https://www.thelancet.com/journals/lancet/article/PIIS0140673605677124/fulltext
- Merck & Co celebrated victory earlier this month after a New Jersey jury ruled that the company's anti-inflammatory drug rofecoxib (Vioxx) did not cause the heart …
Vioxx: an unequal partnership between safety and efficacy - The …
- https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)17198-5/fulltext
- Rofecoxib (Vioxx) is, or was, Merck and Co's leading drug for control of acute pain, and pain associated with osteoarthritis, rheumatoid arthritis, and menstruation. Last …
Discontinuation of Vioxx - The Lancet
- https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)17656-3/fulltext
- On Sept 30, 2004, allegedly in response to the results of the APPROVe study, Merck withdrew rofecoxib from the market. Although The Lancetinitially praised Merck's …
Discontinuation of Vioxx - The Lancet
- https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)17659-9/fulltext
- Merck has withdrawn rofecoxib (Vioxx) worldwide because, in a placebo-controlled trial for colon cancer progression, its use was associated with an increased …
Discontinuation of Vioxx - The Lancet
- https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)17658-7/fulltext
- By contrast with Kim and Reicin's and Jack Nyberg's suggestion, the increased risk of myocardial infarction associated with use of rofecoxib in trials with an external …
Discontinuation of Vioxx - The Lancet
- https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)17655-1/fulltext
- The results of Jüni and colleagues' meta-analysis1 seem to make very obvious the case against Vioxx with little room for argument. Unfortunately, the statistical …
What have we learnt from Vioxx? - PMC - National Center for ...
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779871/
- The New England Journal of Medicine reported problems with the study in an “expression of concern” published in 2006, w10 and the editor in chief has said that the …
Timeline: The Rise and Fall of Vioxx : NPR - NPR.org
- https://www.npr.org/2007/11/10/5470430/timeline-the-rise-and-fall-of-vioxx
- Merck voluntarily withdrew Vioxx from the market in 2004. Research published in the medical journal Lancet estimates that 88,000 Americans had heart …
Discontinuation of Vioxx - The Lancet
- https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)17653-8/fulltext
- Peter Jüni and colleagues1 conclude health authorities should have withdrawn rofecoxib several years before the APPROVe study2 results were made available in …
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