Scottish Biomedical Nav1.7

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The role of Nav1.7 in human nociceptors: insights from …

https://pubmed.ncbi.nlm.nih.gov/30720580/

The IEM mutation induced a hyperpolarizing shift of NaV activation, which leads to activation of NaV1.7 at more negative potentials. Our results indicate that NaV1.7 is not active …

Navigating a new path to Nav1.7 for pain - Nature

https://www.nature.com/articles/d41573-021-00197-2

Cai, S. et al. Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents. Sci. Transl Med. 13, eabh1314 (2021) Article PubMed …

The NaV1.7 sodium channel: from molecule …

https://www.nature.com/articles/nrn3404/

Mutations inSCN9A, which encodes the voltage-gated sodium channel NaV1.7, can lead to severe …

Fluorescence labeling of a NaV1.7-targeted peptide for …

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225226/

HEK293 cells stably expressing the human Na V channel β1 subunit (hNa V β1) in combination with the α subunit hNa V 1.1, hNa V 1.2, hNa V 1.3, hNa V 1.4, hNa V …

Fluorescence labeling of a NaV1.7-targeted peptide …

https://ejnmmires.springeropen.com/track/pdf/10.1186/s13550-020-00630-4.pdf

Fluorescence labeling of a NaV1.7-targeted ... V1.7 (Scottish Biomedical, Glasgow, UK) were cultured in DMEM/F-12 media (1:1), supplemented with 10% fetal bovine serum, …

Ion Channel ScReening - SB Drug Discovery

https://www.sbdrugdiscovery.com/ion-channel-overview.asp

At SB Drug Discovery, we understand that our clients have diverse - and typically complex - ion channel research needs. That's why we offer a flexible and innovative range of drug …

Regulation of Nav1.7: A Conserved SCN9A Natural …

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128830

The Nav1.7 voltage-gated sodium channel, encoded by SCN9A, is critical for human pain perception yet the transcriptional and post-transcriptional mechanisms that …

Anti-Nav1.7 antibody (ab65167) | Abcam

https://www.abcam.com/nav17-antibody-ab65167.html

Atmaramani RR et al. Conserved Expression of Nav1.7 and Nav1.8 Contribute to the Spontaneous and Thermally Evoked Excitability in IL-6 and NGF-Sensitized Adult …

Function and regulation of sodium channel NaV1.7 in pain

https://www.ucl.ac.uk/wolfson-institute-biomedical-research/function-and-regulation-sodium-channel-nav17-pain

Pain is a major clinical problem and many types of chronic pain are difficult to treat. Both human and mouse genetic studies show that the voltage-gated sodium channel Na V 1.7 …

Ion Channel for Pain Drugs Unveiled by Scottish Biomedical

https://www.biospace.com/article/releases/ion-channel-for-pain-drugs-unveiled-by-scottish-biomedical-/

Scottish Biomedical also has electrophysiology in house and can offer this in combination with calcium imaging. The entire sodium panel (Nav1.1 to Nav1.9) will be …

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